Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p291 | (1) | WCRB2014

Effect of pentraxin 3 on inflammation-induced fetal loss

Bonfiglio Rita , Camaioni Antonella , Palone Francesca , Bottazzi Barbara , Sironi Marina , Garlanda Cecilia , Salvatori Giovanni , Mantovani Alberto , Salustri Antonietta

Pentraxin 3 (PTX3) is an essential component of the innate immunity with a non-redundant role in conferring resistance to pathogens and in modulating inflammatory reactions in several diseases. Pregnancy is characterized by mild systemic immunosuppression and inflammation. An uncontrolled immune activation at the fetal–maternal interface caused by bacterial infections or inflammatory stimuli is associated with high risk of miscarriage both in mice and in women. In this st...